Studies of genotoxicity and mutagenicity of nitroimidazoles: demystifying this critical relationship with the nitro group

Nitroimidazoles exhibit high microbicidal activity, but mutagenic, genotoxic and cytotoxic properties have been attributed to the presence of the nitro group. However, we synthesised nitroimidazoles with activity against the trypomastigotes of Trypanosoma cruzi, but that were not genotoxic. Herein,...

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Detalles Bibliográficos
Autores principales: Boechat, Núbia, Carvalho, Alcione S, Salomão, Kelly, de Castro, Solange L, Araujo-Lima, Carlos F, Mello, Francisco VC, Felzenszwalb, Israel, Aiub, Claudia AF, Conde, Taline Ramos, Zamith, Helena PS, Skupin, Rolf, Haufe, Günter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501412/
https://www.ncbi.nlm.nih.gov/pubmed/26018452
http://dx.doi.org/10.1590/0074-02760140248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501412/
https://www.ncbi.nlm.nih.gov/pubmed/26018452
http://dx.doi.org/10.1590/0074-02760140248

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