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A three-step MTOC fragmentation mechanism facilitates bipolar spindle assembly in mouse oocytes
Assembly of a bipolar microtubule spindle is essential for accurate chromosome segregation. In somatic cells, spindle bipolarity is determined by the presence of exactly two centrosomes. Remarkably, mammalian oocytes do not contain canonical centrosomes. This study reveals that mouse oocytes assembl...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Pub. Group
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501430/ https://www.ncbi.nlm.nih.gov/pubmed/26147444 http://dx.doi.org/10.1038/ncomms8217 |