Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation

Damaged mitochondria are removed by mitophagy. Although Atg32 is essential for mitophagy in yeast, no Atg32 homologue has been identified in mammalian cells. Here, we show that Bcl-2-like protein 13 (Bcl2-L-13) induces mitochondrial fragmentation and mitophagy in mammalian cells. First, we hypothesi...

Descripción completa

Detalles Bibliográficos
Autores principales: Murakawa, Tomokazu, Yamaguchi, Osamu, Hashimoto, Ayako, Hikoso, Shungo, Takeda, Toshihiro, Oka, Takafumi, Yasui, Hiroki, Ueda, Hiromichi, Akazawa, Yasuhiro, Nakayama, Hiroyuki, Taneike, Manabu, Misaka, Tomofumi, Omiya, Shigemiki, Shah, Ajay M., Yamamoto, Akitsugu, Nishida, Kazuhiko, Ohsumi, Yoshinori, Okamoto, Koji, Sakata, Yasushi, Otsu, Kinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501433/
https://www.ncbi.nlm.nih.gov/pubmed/26146385
http://dx.doi.org/10.1038/ncomms8527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501433/
https://www.ncbi.nlm.nih.gov/pubmed/26146385
http://dx.doi.org/10.1038/ncomms8527

Ejemplares similares