Metronomic vinorelbine: Anti-angiogenic activity in vitro in normoxic and severe hypoxic conditions, and severe hypoxia-induced resistance to its anti-proliferative effect with reversal by Akt inhibition

Metronomic chemotherapy is the protracted, dense administration of low sub-toxic doses of chemotherapy, to inhibit tumor angiogenesis. Vinorelbine is an orally bioavailable vinca alkaloid shown to be useable for metronomic administration. In clinical trials, metronomic vinorelbine has been demonstra...

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Detalles Bibliográficos
Autores principales: MAVROEIDIS, L., SHELDON, H., BRIASOULIS, E., MARSELOS, M., PAPPAS, P., HARRIS, A.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501653/
https://www.ncbi.nlm.nih.gov/pubmed/26095084
http://dx.doi.org/10.3892/ijo.2015.3059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501653/
https://www.ncbi.nlm.nih.gov/pubmed/26095084
http://dx.doi.org/10.3892/ijo.2015.3059

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