Regulation of expression of O(6)-methylguanine-DNA methyltransferase and the treatment of glioblastoma (Review)

O-6-methylguanine-DNA methyltransferase (MGMT) is an abundantly expressed nuclear protein dealkylating O(6)-methylguanine (O(6)-MG) DNA residue, thus correcting the mismatches of O(6)-MG with a thymine residue during DNA replication. The dealkylating effect of MGMT is relevant not only in repairing...

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Detalles Bibliográficos
Autores principales: CABRINI, GIULIO, FABBRI, ENRICA, NIGRO, CRISTIANA LO, DECHECCHI, MARIA CRISTINA, GAMBARI, ROBERTO
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501657/
https://www.ncbi.nlm.nih.gov/pubmed/26035292
http://dx.doi.org/10.3892/ijo.2015.3026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501657/
https://www.ncbi.nlm.nih.gov/pubmed/26035292
http://dx.doi.org/10.3892/ijo.2015.3026

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