Cargando…
Regulation of expression of O(6)-methylguanine-DNA methyltransferase and the treatment of glioblastoma (Review)
O-6-methylguanine-DNA methyltransferase (MGMT) is an abundantly expressed nuclear protein dealkylating O(6)-methylguanine (O(6)-MG) DNA residue, thus correcting the mismatches of O(6)-MG with a thymine residue during DNA replication. The dealkylating effect of MGMT is relevant not only in repairing...
Autores principales: | CABRINI, GIULIO, FABBRI, ENRICA, NIGRO, CRISTIANA LO, DECHECCHI, MARIA CRISTINA, GAMBARI, ROBERTO |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501657/ https://www.ncbi.nlm.nih.gov/pubmed/26035292 http://dx.doi.org/10.3892/ijo.2015.3026 |
Ejemplares similares
-
Effect of alternative temozolomide schedules on glioblastoma O(6)-methylguanine-DNA methyltransferase activity and survival
por: Robinson, C G, et al.
Publicado: (2010) -
Regulation of O6-methylguanine-DNA methyltransferase by methionine in human tumour cells.
por: Kokkinakis, D. M., et al.
Publicado: (1997) -
Enhancing the Expression of CFTR Using Antisense Molecules against MicroRNA miR-145-5p
por: Finotti, Alessia, et al.
Publicado: (2019) -
O6-methylguanine-DNA methyltransferase activities in biopsies of human melanoma tumours.
por: Egyházi, S., et al.
Publicado: (1995) -
O(6)-methylguanine-DNA methyltransferase in equine sarcoids: molecular and epigenetic analysis
por: Altamura, Gennaro, et al.
Publicado: (2012)