Elevated cyclin A associated kinase activity promotes sensitivity of metastatic human cancer cells to DNA antimetabolite drug

Drug resistance is a major obstacle in successful systemic therapy of metastatic cancer. We analyzed the involvement of cell cycle regulatory proteins in eliciting response to N (phosphonoacetyl)-L-aspartate (PALA), an inhibitor of de novo pyrimidine synthesis, in two metastatic variants of human ca...

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Detalles Bibliográficos
Autores principales: WANG, JIN, YIN, HAILIN, PANANDIKAR, ASHWINI, GANDHI, VARSHA, SEN, SUBRATA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501665/
https://www.ncbi.nlm.nih.gov/pubmed/26058363
http://dx.doi.org/10.3892/ijo.2015.3037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501665/
https://www.ncbi.nlm.nih.gov/pubmed/26058363
http://dx.doi.org/10.3892/ijo.2015.3037

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