Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors

A series of compounds based on the dipeptidyl nitrile scaffold were synthesized and assayed for their inhibitory activity against the T. cruzi cysteine protease cruzain. Structure activity relationships (SARs) were established using three, eleven and twelve variations respectively at the P1, P2 and...

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Detalles Bibliográficos
Autores principales: Avelar, Leandro A. A., Camilo, Cristian D., de Albuquerque, Sérgio, Fernandes, William B., Gonçalez, Cristiana, Kenny, Peter W., Leitão, Andrei, McKerrow, James H., Montanari, Carlos A., Orozco, Erika V. Meñaca, Ribeiro, Jean F. R., Rocha, Josmar R., Rosini, Fabiana, Saidel, Marta E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501791/
https://www.ncbi.nlm.nih.gov/pubmed/26173110
http://dx.doi.org/10.1371/journal.pntd.0003916

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501791/
https://www.ncbi.nlm.nih.gov/pubmed/26173110
http://dx.doi.org/10.1371/journal.pntd.0003916

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