Identification of reproducible drug-resistance-related dysregulated genes in small-scale cancer cell line experiments

Researchers usually measure only a few technical replicates of two types of cell line, resistant or sensitive to a drug, and use a fold-change (FC) cut-off value to detect differentially expressed (DE) genes. However, the FC cut-off lacks statistical control and is biased towards the identification...

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Detalles Bibliográficos
Autores principales: Ao, Lu, Yan, Haidan, Zheng, Tingting, Wang, Hongwei, Tong, Mengsha, Guan, Qingzhou, Li, Xiangyu, Cai, Hao, Li, Mengyao, Guo, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502408/
https://www.ncbi.nlm.nih.gov/pubmed/26173481
http://dx.doi.org/10.1038/srep11895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502408/
https://www.ncbi.nlm.nih.gov/pubmed/26173481
http://dx.doi.org/10.1038/srep11895

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