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Identification of reproducible drug-resistance-related dysregulated genes in small-scale cancer cell line experiments
Researchers usually measure only a few technical replicates of two types of cell line, resistant or sensitive to a drug, and use a fold-change (FC) cut-off value to detect differentially expressed (DE) genes. However, the FC cut-off lacks statistical control and is biased towards the identification...
Autores principales: | Ao, Lu, Yan, Haidan, Zheng, Tingting, Wang, Hongwei, Tong, Mengsha, Guan, Qingzhou, Li, Xiangyu, Cai, Hao, Li, Mengyao, Guo, Zheng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502408/ https://www.ncbi.nlm.nih.gov/pubmed/26173481 http://dx.doi.org/10.1038/srep11895 |
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