Copper depletion inhibits CoCl(2)-induced aggressive phenotype of MCF-7 cells via downregulation of HIF-1 and inhibition of Snail/Twist-mediated epithelial-mesenchymal transition

Copper, a strictly regulated trace element, is essential for many physiological processes including angiogenesis. Dysregulated angiogenesis has been associated with increased copper in tumors, and thus copper chelators have been used to inhibit tumor angiogenesis. However, it remains unclear whether...

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Detalles Bibliográficos
Autores principales: Li, Shun, Zhang, Jing, Yang, Hong, Wu, Chunhui, Dang, Xitong, Liu, Yiyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502431/
https://www.ncbi.nlm.nih.gov/pubmed/26174737
http://dx.doi.org/10.1038/srep12410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502431/
https://www.ncbi.nlm.nih.gov/pubmed/26174737
http://dx.doi.org/10.1038/srep12410

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