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Differential connectivity of splicing activators and repressors to the human spliceosome

BACKGROUND: During spliceosome assembly, protein-protein interactions (PPI) are sequentially formed and disrupted to accommodate the spatial requirements of pre-mRNA substrate recognition and catalysis. Splicing activators and repressors, such as SR proteins and hnRNPs, modulate spliceosome assembly...

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Detalles Bibliográficos
Autores principales:	Akerman, Martin, Fregoso, Oliver I., Das, Shipra, Ruse, Cristian, Jensen, Mads A., Pappin, Darryl J., Zhang, Michael Q., Krainer, Adrian R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502471/ https://www.ncbi.nlm.nih.gov/pubmed/26047612 http://dx.doi.org/10.1186/s13059-015-0682-5

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