Motif signatures in stretch enhancers are enriched for disease-associated genetic variants

BACKGROUND: Stretch enhancers (SEs) are large chromatin-defined regulatory elements that are at least 3,000 base pairs (bps) long, in contrast to the median enhancer length of 800 bps. SEs tend to be cell-type specific, regulate cell-type specific gene expression, and are enriched in disease-associa...

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Detalles Bibliográficos
Autores principales: Quang, Daniel X, Erdos, Michael R, Parker, Stephen C J, Collins, Francis S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502539/
https://www.ncbi.nlm.nih.gov/pubmed/26180553
http://dx.doi.org/10.1186/s13072-015-0015-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502539/
https://www.ncbi.nlm.nih.gov/pubmed/26180553
http://dx.doi.org/10.1186/s13072-015-0015-7

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