A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors

Autophagy has been implicated in the progression and chemoresistance of various cancers. In this study, we have shown that osteosarcoma Saos-2 cells lacking ATG4B, a cysteine proteinase that activates LC3B, are defective in autophagy and fail to form tumors in mouse models. By combining in silico do...

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Detalles Bibliográficos
Autores principales: Akin, Debra, Wang, S Keisin, Habibzadegah-Tari, Pouran, Law, Brian, Ostrov, David, Li, Min, Yin, Xiao-Ming, Kim, Jae-Sung, Horenstein, Nicole, Dunn, William A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Translational Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502682/
https://www.ncbi.nlm.nih.gov/pubmed/25483883
http://dx.doi.org/10.4161/auto.32229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502682/
https://www.ncbi.nlm.nih.gov/pubmed/25483883
http://dx.doi.org/10.4161/auto.32229

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