Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A

Autophagy is a catabolic lysosomal degradation process essential for cellular homeostasis and cell survival. Dysfunctional autophagy has been associated with a wide range of human diseases, e.g., cancer and neurodegenerative diseases. A large number of small molecules that modulate autophagy have be...

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Detalles Bibliográficos
Autores principales: Lu, Yingying, Dong, Shichen, Hao, Baixia, Li, Chang, Zhu, Kaiyuan, Guo, Wenjing, Wang, Qian, Cheung, King-Ho, Wong, Connie WM, Wu, Wu-Tian, Markus, Huss, Yue, Jianbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502727/
https://www.ncbi.nlm.nih.gov/pubmed/25483964
http://dx.doi.org/10.4161/auto.32200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502727/
https://www.ncbi.nlm.nih.gov/pubmed/25483964
http://dx.doi.org/10.4161/auto.32200

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