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Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A
Autophagy is a catabolic lysosomal degradation process essential for cellular homeostasis and cell survival. Dysfunctional autophagy has been associated with a wide range of human diseases, e.g., cancer and neurodegenerative diseases. A large number of small molecules that modulate autophagy have be...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502727/ https://www.ncbi.nlm.nih.gov/pubmed/25483964 http://dx.doi.org/10.4161/auto.32200 |