Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity

During macroautophagy, conjugation of ATG12 to ATG5 is essential for LC3 lipidation and autophagosome formation. Additionally, ATG12 has ATG5-independent functions in diverse processes including mitochondrial fusion and mitochondrial-dependent apoptosis. In this study, we investigated the regulation...

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Detalles Bibliográficos
Autores principales: Haller, Martina, Hock, Andreas K, Giampazolias, Evangelos, Oberst, Andrew, Green, Douglas R, Debnath, Jayanta, Ryan, Kevin M, Vousden, Karen H, Tait, Stephen W G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Basic Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502749/
https://www.ncbi.nlm.nih.gov/pubmed/25629932
http://dx.doi.org/10.4161/15548627.2014.981914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502749/
https://www.ncbi.nlm.nih.gov/pubmed/25629932
http://dx.doi.org/10.4161/15548627.2014.981914

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