Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF

Recent evidence suggests that autophagy may favor fibrosis through enhanced differentiation of fibroblasts in myofibroblasts. Here, we sought to characterize the mediators and signaling pathways implicated in autophagy-induced myofibroblast differentiation. Fibroblasts, serum starved for up to 4 d,...

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Detalles Bibliográficos
Autores principales: Bernard, Monique, Dieudé, Mélanie, Yang, Bing, Hamelin, Katia, Underwood, Katy, Hébert, Marie-Josée
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Basic Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502773/
https://www.ncbi.nlm.nih.gov/pubmed/25495560
http://dx.doi.org/10.4161/15548627.2014.981786

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502773/
https://www.ncbi.nlm.nih.gov/pubmed/25495560
http://dx.doi.org/10.4161/15548627.2014.981786

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