Cargando…

Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF

Recent evidence suggests that autophagy may favor fibrosis through enhanced differentiation of fibroblasts in myofibroblasts. Here, we sought to characterize the mediators and signaling pathways implicated in autophagy-induced myofibroblast differentiation. Fibroblasts, serum starved for up to 4 d,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bernard, Monique, Dieudé, Mélanie, Yang, Bing, Hamelin, Katia, Underwood, Katy, Hébert, Marie-Josée
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2015
Materias:	Basic Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502773/ https://www.ncbi.nlm.nih.gov/pubmed/25495560 http://dx.doi.org/10.4161/15548627.2014.981786

Ejemplares similares

Inhibition of CTGF ameliorates peritoneal fibrosis through suppression of fibroblast and myofibroblast accumulation and angiogenesis
por: Sakai, Norihiko, et al.
Publicado: (2017)

Endothelial Dysfunction in Kidney Transplantation
por: Cardinal, Héloïse, et al.
Publicado: (2018)

The Impact of Programmed Cell Death on the Formation of Tertiary Lymphoid Structures
por: Dieudé, Mélanie, et al.
Publicado: (2021)

Pharmacological inhibition of lysosomes activates the MTORC1 signaling pathway in chondrocytes in an autophagy-independent manner
por: Newton, Phillip T, et al.
Publicado: (2015)

Amlodipine Improves Spinal Cord Injury Repair by Inhibiting Motoneuronal Apoptosis Through Autophagy Upregulation
por: Huang, Yang, et al.
Publicado: (2022)

Regulation of adiposity by mTORC1
por: Magdalon, Juliana, et al.
Publicado: (2017)

Tamoxifen decreases the myofibroblast count in the healing bile duct tissue of pigs
por: Siqueira, Orlando Hiroshi Kiono, et al.
Publicado: (2013)

Suppression of MAPK/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells
por: Basu, Subhasree, et al.
Publicado: (2014)

MHC class I antigen cross-presentation mediated by PapMV nanoparticles in human antigen-presenting cells is dependent on autophagy
por: Possamaï, David, et al.
Publicado: (2021)

Activin a promotes myofibroblast differentiation of endometrial mesenchymal stem cells via STAT3-dependent Smad/CTGF pathway
por: Zhang, Zhenzhen, et al.
Publicado: (2019)

Female Gene Networks Are Expressed in Myofibroblast-Like Smooth Muscle Cells in Vulnerable Atherosclerotic Plaques
por: Diez Benavente, Ernest, et al.
Publicado: (2023)

Hyperactivity of mTORC1 or mTORC2-dependent signaling causes epilepsy downstream of somatic PTEN loss
por: Cullen, Erin R., et al.
Publicado: (2023)

mTORC2 Steals the Spotlight
por: Jansen, Laura A.
Publicado: (2020)

Per2-Mediated Vascular Dysfunction Is Caused by the Upregulation of the Connective Tissue Growth Factor (CTGF)
por: Jadhav, Vaishnavi, et al.
Publicado: (2016)

CTGF upregulation correlates with MMP-9 level in airway remodeling in a murine model of asthma
por: Lin, Sheng-Chieh, et al.
Publicado: (2016)

Extracellular ATP promotes angiogenesis and adhesion of TNBC cells to endothelial cells via upregulation of CTGF
por: Zhou, Yan‐Ting, et al.
Publicado: (2022)

Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids
por: Sahani, Mayurbhai Himatbhai, et al.
Publicado: (2014)

Increased Levels of Phosphorylated ERK Induce CTGF Expression in Autophagy-Deficient Mouse Hepatocytes
por: Seo, Hye-Young, et al.
Publicado: (2022)

Hsp83 loss suppresses proteasomal activity resulting in an upregulation of caspase-dependent compensatory autophagy
por: Choutka, Courtney, et al.
Publicado: (2017)

Cucurbitacin E Induces Autophagy via Downregulating mTORC1 Signaling and Upregulating AMPK Activity
por: Zha, Qing-Bing, et al.
Publicado: (2015)

NLRP3 and downstream cytokine expression elevated in the monocytes of patients with coronary artery disease
por: Wang, Lili, et al.
Publicado: (2014)

Central role of mTORC1 downstream of YAP/TAZ in hepatoblastoma development
por: Liu, Pin, et al.
Publicado: (2017)

CTGF in kidney fibrosis and glomerulonephritis
por: Toda, Naohiro, et al.
Publicado: (2018)

Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosis
por: Li, Jianzhong, et al.
Publicado: (2015)

DNA extraction from archived hematoxylin and eosin-stained tissue slides for downstream molecular analysis
por: Ramesh, Pushkal Sinduvadi, et al.
Publicado: (2019)

Depletion of MRPL35 inhibits gastric carcinoma cell proliferation by regulating downstream signaling proteins
por: Yuan, Ling, et al.
Publicado: (2021)

N-myc downstream regulated gene 1 inhibition of tumor progression in Caco2 cells
por: He, Yi-Xiao, et al.
Publicado: (2022)

CTGF-mediated autophagy-senescence transition in tumor stroma promotes anabolic tumor growth and metastasis
por: Prabhu, Varun V., et al.
Publicado: (2012)

Hypothermic Perfusion Modifies the Association Between Anti-LG3 Antibodies and Delayed Graft Function in Kidney Recipients
por: Mawad, Habib, et al.
Publicado: (2023)

Correlation of CTGF gene promoter methylation with CTGF expression in type 2 diabetes mellitus with or without nephropathy
por: ZHANG, HAO, et al.
Publicado: (2014)

Daikenchuto (Da-Jian-Zhong-Tang) ameliorates intestinal fibrosis by activating myofibroblast transient receptor potential ankyrin 1 channel
por: Hiraishi, Keizo, et al.
Publicado: (2018)

Glucocorticoid receptor regulates expression of microRNA-22 and downstream signaling pathway in apoptosis of pancreatic acinar cells
por: Fu, Qiang, et al.
Publicado: (2018)

Disruption of the Extracellular Matrix Progressively Impairs Central Nervous System Vascular Maturation Downstream of β-Catenin Signaling
por: Jensen, Lasse D., et al.
Publicado: (2019)

The altered mechanical phenotype of fetal fibroblasts hinders myofibroblast differentiation
por: Jerrell, Rachel J., et al.
Publicado: (2018)

The CTGF -945GC polymorphism is not associated with plasma CTGF and does not predict nephropathy or outcome in type 1 diabetes
por: Dendooven, Amélie, et al.
Publicado: (2011)

An expanded role for mTORC1 in autophagy
por: Kim, Young-Mi, et al.
Publicado: (2015)

mTORC1 as the main gateway to autophagy
por: Rabanal-Ruiz, Yoana, et al.
Publicado: (2017)

Upregulation of SCUBE1 in Dengue Virus Infection
por: Ali, Hirowati, et al.
Publicado: (2019)

Evolving Insights on Metabolism, Autophagy, and Epigenetics in Liver Myofibroblasts
por: Nwosu, Zeribe C., et al.
Publicado: (2016)

Expression of Interleukin-26 is upregulated in inflammatory bowel disease
por: Fujii, Makoto, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_2m3r4abfnnrb24qektpvcsmhmq