Using BRAF(V600E) as a marker of autophagy dependence in pediatric brain tumors

Autophagy inhibition is a potential therapeutic strategy in central nervous system (CNS) tumors. The BRAF(V600E) mutation is known to affect autophagy. Our studies indicate CNS tumor cells with BRAF(V600E) mutant cells (but not wild type) display high rates of induced autophagy, are sensitive to aut...

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Detalles Bibliográficos
Autores principales: Levy, Jean M Mulcahy, Foreman, Nicholas K, Thorburn, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Autophagic Punctum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502777/
https://www.ncbi.nlm.nih.gov/pubmed/25484091
http://dx.doi.org/10.4161/auto.36138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502777/
https://www.ncbi.nlm.nih.gov/pubmed/25484091
http://dx.doi.org/10.4161/auto.36138

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