Impacts of the Glucuronidase Genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 on Tamoxifen Metabolism in Breast Cancer Patients

Tamoxifen is used to prevent and treat estrogen-dependent breast cancer. It is described as a prodrug since most of its antiestrogen effects are exerted through its hydroxylated metabolites 4-OH-tamoxifen and endoxifen. In prior work, we correlated optimal plasma levels of these metabolites with cer...

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Detalles Bibliográficos
Autores principales: Romero-Lorca, Alicia, Novillo, Apolonia, Gaibar, María, Bandrés, Fernando, Fernández-Santander, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503404/
https://www.ncbi.nlm.nih.gov/pubmed/26176234
http://dx.doi.org/10.1371/journal.pone.0132269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503404/
https://www.ncbi.nlm.nih.gov/pubmed/26176234
http://dx.doi.org/10.1371/journal.pone.0132269

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