Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling

BACKGROUND & AIMS: In cholestatic syndromes, body accumulation of bile acids is thought to cause itching. However, the mechanisms supporting this effect remain elusive. Recently, GPBAR1 (TGR5) a G-protein coupled receptor has been shown to mediate itching caused by intradermal administration of...

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Detalles Bibliográficos
Autores principales: Cipriani, Sabrina, Renga, Barbara, D’Amore, Claudio, Simonetti, Michele, De Tursi, Antonio Angelo, Carino, Adriana, Monti, Maria Chiara, Sepe, Valentina, Zampella, Angela, Fiorucci, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503431/
https://www.ncbi.nlm.nih.gov/pubmed/26177448
http://dx.doi.org/10.1371/journal.pone.0129866

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503431/
https://www.ncbi.nlm.nih.gov/pubmed/26177448
http://dx.doi.org/10.1371/journal.pone.0129866

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