Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes

Human pluripotent stem cell-derived hepatocytes have the potential to provide in vitro model systems for drug discovery and hepatotoxicity testing. However, these cells are currently unsuitable for drug toxicity and efficacy testing because of their limited expression of genes encoding drug-metaboli...

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Detalles Bibliográficos
Autores principales: Park, Han-Jin, Choi, Young-Jun, Kim, Ji Woo, Chun, Hang-Suk, Im, Ilkyun, Yoon, Seokjoo, Han, Yong-Mahn, Song, Chang-Woo, Kim, Hyemin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503736/
https://www.ncbi.nlm.nih.gov/pubmed/26177506
http://dx.doi.org/10.1371/journal.pone.0132992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503736/
https://www.ncbi.nlm.nih.gov/pubmed/26177506
http://dx.doi.org/10.1371/journal.pone.0132992

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