Cargando…

Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes

Human pluripotent stem cell-derived hepatocytes have the potential to provide in vitro model systems for drug discovery and hepatotoxicity testing. However, these cells are currently unsuitable for drug toxicity and efficacy testing because of their limited expression of genes encoding drug-metaboli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Han-Jin, Choi, Young-Jun, Kim, Ji Woo, Chun, Hang-Suk, Im, Ilkyun, Yoon, Seokjoo, Han, Yong-Mahn, Song, Chang-Woo, Kim, Hyemin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503736/ https://www.ncbi.nlm.nih.gov/pubmed/26177506 http://dx.doi.org/10.1371/journal.pone.0132992

Ejemplares similares

Xeno-sensing activity of the aryl hydrocarbon receptor in human pluripotent stem cell-derived hepatocyte-like cells
por: Kim, Hye-Min, et al.
Publicado: (2016)

Highlight report: Monitoring cytochrome P450 activities in living hepatocytes
por: Ghallab, Ahmed
Publicado: (2017)

Inflammatory signaling on cytochrome P450-mediated drug metabolism in hepatocytes
por: Wang, Xiaokang, et al.
Publicado: (2022)

Effects of Cytochrome P450 Inhibitors on Itraconazole and Fluconazole Induced Cytotoxicity in Hepatocytes
por: Somchit, Nhareet, et al.
Publicado: (2009)

Bosentan and Rifampin Interactions Modulate Influx Transporter and Cytochrome P450 Expression and Activities in Primary Human Hepatocytes
por: Han, Kyoung-Moon, et al.
Publicado: (2017)

Is cytochrome P-450 transported from the endoplasmic reticulum to the Golgi apparatus in rat hepatocytes?
Publicado: (1985)

Changes in the Quantity and Activity of Cytochrome P‐450 Isozymes in Primary Cultured Rat Hepatocytes
por: Namiki, Masayuki, et al.
Publicado: (1989)

Functioning of Microsomal Cytochrome P450s: Murburn Concept Explains the Metabolism of Xenobiotics in Hepatocytes
por: Manoj, Kelath Murali, et al.
Publicado: (2016)

Mertansine Inhibits mRNA Expression and Enzyme Activities of Cytochrome P450s and Uridine 5′-Diphospho-Glucuronosyltransferases in Human Hepatocytes and Liver Microsomes
por: Choi, Won-Gu, et al.
Publicado: (2020)

Immunoelectron microscope localization of cytochrome P-450 on microsomes and other membrane structures of rat hepatocytes
Publicado: (1978)

Evaluation of RNA-knockdown strategies for modulation of cytochrome P450 reductase activity in mouse hepatocytes
por: Mackenzie, Neil CW, et al.
Publicado: (2010)

Regulation of Cytochrome P450 2a5 by Artemisia capillaris and 6,7-Dimethylesculetin in Mouse Hepatocytes
por: Kim, Sangsoo Daniel, et al.
Publicado: (2021)

Effects of Diminished NADPH:cytochrome P450 Reductase in Human Hepatocytes on Lipid and Bile Acid Homeostasis
por: Heintze, Tamara, et al.
Publicado: (2021)

Effects of short-chain per- and polyfluoroalkyl substances (PFAS) on human cytochrome P450 (CYP450) enzymes and human hepatocytes: An in vitro study
por: Solan, Megan E., et al.
Publicado: (2023)

Biosynthesis of cytochrome P-450 on membrane-bound ribosomes and its subsequent incorporation into rough and smooth microsomes in rat hepatocytes
Publicado: (1979)

In Vitro Differentiation of Embryonic and Adult Stem Cells into Hepatocytes: State of the Art
por: Snykers, Sarah, et al.
Publicado: (2009)

Alterations in the hepatocyte epigenetic landscape in steatosis
por: Maji, Ranjan Kumar, et al.
Publicado: (2023)

Effects of Garlic on Cytochromes P450 2C9- and 3A4-Mediated Drug Metabolism in Human Hepatocytes
por: Ho, Beatrice E., et al.
Publicado: (2010)

METTL3 exacerbates insulin resistance in hepatocytes by regulating m(6)A modification of cytochrome P450 2B6
por: Li, Yongqing, et al.
Publicado: (2023)

Lineage-specific Expression of miR-200 Family in Human Embryonic Stem Cells during In Vitro Differentiation
por: Kim, Yeji, et al.
Publicado: (2017)

The FMN “140s Loop” of Cytochrome P450 Reductase Controls Electron Transfer to Cytochrome P450
por: Rwere, Freeborn, et al.
Publicado: (2021)

Possibility of Undifferentiated Human Thigh Adipose Stem Cells Differentiating into Functional Hepatocytes
por: Lee, Jong Hoon, et al.
Publicado: (2012)

A Novel System for Evaluating the Inhibition Effect of Drugs on Cytochrome P450 Enzymes in vitro Based on Human-Induced Hepatocytes (hiHeps)
por: Li, Yan, et al.
Publicado: (2021)

Inhibition of Cytochrome P450 by Propolis in Human Liver Microsomes
por: Ryu, Chang Seon, et al.
Publicado: (2016)

Enhancement of hepatocyte differentiation from human embryonic stem cells by Chinese medicine Fuzhenghuayu
por: Chen, Jiamei, et al.
Publicado: (2016)

Necroptosis Is a Mechanism of Death in Mouse Induced Hepatocyte-Like Cells Reprogrammed from Mouse Embryonic Fibroblasts
por: Lee, Yun-Suk, et al.
Publicado: (2018)

Functional 3D Human Primary Hepatocyte Spheroids Made by Co-Culturing Hepatocytes from Partial Hepatectomy Specimens and Human Adipose-Derived Stem Cells
por: No, Da Yoon, et al.
Publicado: (2012)

The Efficacy of the Hepatocyte Spheroids for Hepatocyte Transplantation
por: Shibuya, Kazuaki, et al.
Publicado: (2021)

Melatonin Regulates Iron Homeostasis by Inducing Hepcidin Expression in Hepatocytes
por: Park, Woo-Ram, et al.
Publicado: (2022)

Intestinal Clostridioides difficile Can Cause Liver Injury through the Occurrence of Inflammation and Damage to Hepatocytes
por: Lee, Soomin, et al.
Publicado: (2020)

Assessment of the hepatocyte protective effects of gypenoside and its phosphorylated derivative against DHAV-1 infection on duck embryonic hepatocytes
por: Du, Hongxu, et al.
Publicado: (2019)

NADPH-cytochrome P450 reductase expression and enzymatic activity in primary-like human hepatocytes and HepG2 cells for in vitro biotransformation studies
por: Schulz, Christian, et al.
Publicado: (2019)

Increased microfilaments in hepatocytes and biliary ductular cells in cholestatic liver diseases.
por: Chung, Kyu-Won, et al.
Publicado: (2002)

New Approaches in the Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells toward Hepatocytes
por: Behbahan, Iman Saramipoor, et al.
Publicado: (2011)

Differentiation and Selection of Hepatocyte Precursors in Suspension Spheroid Culture of Transgenic Murine Embryonic Stem Cells
por: Gabriel, Elke, et al.
Publicado: (2012)

Effect of honokiol on the induction of drug-metabolizing enzymes in human hepatocytes
por: Cho, Yong-Yeon, et al.
Publicado: (2014)

Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions
por: Li, Zhongwen, et al.
Publicado: (2019)

Establishment of a novel hepatocyte model that expresses four cytochrome P450 genes stably via mammalian-derived artificial chromosome for pharmacokinetics and toxicity studies
por: Satoh, Daisuke, et al.
Publicado: (2017)

Immortalization of human hepatocytes from biliary atresia with CDK4(R24C), cyclin D1, and TERT for cytochrome P450 induction testing
por: Nishiwaki, Manami, et al.
Publicado: (2020)

Stem cell-derived polarized hepatocytes
por: Dao Thi, Viet Loan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_6l33h3cpajqg0iodu2sr8e3u99