Inactivation of Retinoblastoma Protein (Rb1) in the Oocyte: Evidence That Dysregulated Follicle Growth Drives Ovarian Teratoma Formation in Mice

The origin of most ovarian tumors is undefined. Here, we report development of a novel mouse model in which conditional inactivation of the tumor suppressor gene Rb1 in oocytes leads to the formation of ovarian teratomas (OTs). While parthenogenetically activated ooctyes are a known source of OT in...

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Detalles Bibliográficos
Autores principales: Yang, Qi-En, Nagaoka, So I., Gwost, Ivy, Hunt, Patricia A., Oatley, Jon M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503754/
https://www.ncbi.nlm.nih.gov/pubmed/26176933
http://dx.doi.org/10.1371/journal.pgen.1005355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503754/
https://www.ncbi.nlm.nih.gov/pubmed/26176933
http://dx.doi.org/10.1371/journal.pgen.1005355

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