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Mesenchymal stromal cell delivery of full-length tumor necrosis factor–related apoptosis-inducing ligand is superior to soluble type for cancer therapy

BACKGROUND AIMS: Mesenchymal stromal cell (MSC) delivery of pro-apoptotic tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is an attractive strategy for anticancer therapy. MSCs expressing full-length human TRAIL (flT) or its soluble form (sT) have previously been shown to be ef...

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Detalles Bibliográficos
Autores principales: Yuan, ZhengQiang, Kolluri, Krishna K., Sage, Elizabeth K., Gowers, Kate H.C., Janes, Sam M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503823/
https://www.ncbi.nlm.nih.gov/pubmed/25888191
http://dx.doi.org/10.1016/j.jcyt.2015.03.603