Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase

Protein arginylation is an emerging post-translational modification that targets a number of metabolic enzymes, however the mechanisms and downstream effects of this modification are unknown. Here we show that lack of arginylation renders cells vulnerable to purine nucleotide synthesis inhibitors an...

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Detalles Bibliográficos
Autores principales: Zhang, Fangliang, Patel, Devang M., Colavita, Kristen, Rodionova, Irina, Buckley, Brian, Scott, David, Kumar, Akhilesh, Shabalina, Svetlana A., Saha, Sougata, Chernov, Mikhail, Osterman, Andrei, Kashina, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503932/
https://www.ncbi.nlm.nih.gov/pubmed/26175007
http://dx.doi.org/10.1038/ncomms8517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503932/
https://www.ncbi.nlm.nih.gov/pubmed/26175007
http://dx.doi.org/10.1038/ncomms8517

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