Cargando…

Uric Acid Produces an Inflammatory Response through Activation of NF-κB in the Hypothalamus: Implications for the Pathogenesis of Metabolic Disorders

Epidemiological studies have shown that an elevated uric acid (UA) level predicts the development of metabolic syndrome and diabetes; however, there is no direct evidence of this, and the underlying mechanism remains unclear. Here, we showed that a high-UA diet triggered the expression of pro-inflam...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Wenjie, Xu, Youzhi, Shao, Xiaoni, Gao, Fabao, Li, Yan, Hu, Jing, Zuo, Zeping, Shao, Xue, Zhou, Liangxue, Zhao, Yinglan, Cen, Xiaobo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503982/ https://www.ncbi.nlm.nih.gov/pubmed/26179594 http://dx.doi.org/10.1038/srep12144

Ejemplares similares

NF-κB Pathways in the Pathogenesis of Multiple Sclerosis and the Therapeutic Implications
por: Leibowitz, Saskia M., et al.
Publicado: (2016)

Lipidomic profiling reveals lipid regulation by a novel LSD1 inhibitor treatment
por: Li, Yan, et al.
Publicado: (2021)

The role of NF-κB in the pathogenesis of glioma
por: Puliyappadamba, Vineshkumar Thidil, et al.
Publicado: (2014)

Natural cyclopeptide RA-V inhibits the NF-κB signaling pathway by targeting TAK1
por: Wang, Zhe, et al.
Publicado: (2018)

Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis
por: Kimura, Yoshitaka, et al.
Publicado: (2021)

Retinal glia and NF-κB in diabetic retinopathy pathogenesis
por: Park, Susanna S.
Publicado: (2023)

NF-κB signaling in inflammation
por: Liu, Ting, et al.
Publicado: (2017)

NF-κB in inflammation and renal diseases
por: Zhang, Haisong, et al.
Publicado: (2015)

Uric Acid Induces Renal Inflammation via Activating Tubular NF-κB Signaling Pathway
por: Zhou, Yang, et al.
Publicado: (2012)

(1)H-NMR based metabonomic profiling of human esophageal cancer tissue
por: Wang, Liang, et al.
Publicado: (2013)

Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression
por: Bellezza, Ilaria, et al.
Publicado: (2010)

Podocyte NF‐κB is dispensable for the pathogenesis of renal ischemia‐reperfusion injury
por: Yamashita, Maho, et al.
Publicado: (2016)

The Role of NF-κB in Intracranial Aneurysm Pathogenesis: A Systematic Review
por: Khan, Dilaware, et al.
Publicado: (2023)

A versatile supramolecular nanoadjuvant that activates NF-κB for cancer immunotherapy
por: Xu, Yan, et al.
Publicado: (2019)

The Use of Juçara (Euterpe edulis Mart.) Supplementation for Suppression of NF-κB Pathway in the Hypothalamus after High-Fat Diet in Wistar Rats
por: Santamarina, Aline Boveto, et al.
Publicado: (2018)

A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode
por: Zeng, Ting, et al.
Publicado: (2019)

The Hypothalamus

Anatomy of the Hypothalamus. Handbook of the Hypothalamus. Volume 1
por: Levitt, Pat
Publicado: (1980)

Phosphatidylserine decarboxylase downregulation in uric acid‑induced hepatic mitochondrial dysfunction and apoptosis
por: Liu, Ning, et al.
Publicado: (2023)

Hypothalamus and amyotrophic lateral sclerosis: potential implications in sleep disorders
por: Gnoni, Valentina, et al.
Publicado: (2023)

Long-Term l-Serine Administration Reduces Food Intake and Improves Oxidative Stress and Sirt1/NFκB Signaling in the Hypothalamus of Aging Mice
por: Zhou, Xihong, et al.
Publicado: (2018)

The Causation of Anemia and the Blood-Changes Produced by Uric Acid
Publicado: (1893)

Atorvastatin Alleviates Experimental Diabetic Cardiomyopathy by Regulating the GSK-3β-PP2Ac-NF-κB Signaling Axis
por: Ren, Xiao-min, et al.
Publicado: (2016)

Immunohistochemical Analysis of Neurotransmitters in Neurosecretory Protein GL-Producing Neurons of the Mouse Hypothalamus
por: Naito, Mana, et al.
Publicado: (2022)

Roles of PPARγ/NF-κB Signaling Pathway in the Pathogenesis of Intrahepatic Cholestasis of Pregnancy
por: Zhang, Yan, et al.
Publicado: (2014)

CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis
por: Willy, Jeffrey A., et al.
Publicado: (2015)

Schisandra extract ameliorates arthritis pathogenesis by suppressing the NF‐κB and MAPK signalling pathways
por: Han, Seong Jae, et al.
Publicado: (2023)

Blooming in the Hypothalamus
por: Rai, Santosh P. V., et al.
Publicado: (2019)

The role of oxidative stress-mediated apoptosis in the pathogenesis of uric acid nephropathy
por: Yang, Lijuan, et al.
Publicado: (2019)

Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review
por: Sharaf El Din, Usama A.A., et al.
Publicado: (2017)

OR22-01 NF-κB Pathway Is Implicated in Thyroid Embryogenesis
por: Vanier, Stéphanie Larrivée, et al.
Publicado: (2020)

Neurofibromatosis Type 2 (NF2) and the Implications for Vestibular Schwannoma and Meningioma Pathogenesis
por: Bachir, Suha, et al.
Publicado: (2021)

Knockout of ASPP2 promotes DEN-induced hepatocarcinogenesis via the NF-κB pathway in mice
por: Wang, Shanshan, et al.
Publicado: (2021)

Clinical Implication of Individually Tailored Segmentation Method for Distorted Hypothalamus in Craniopharyngioma
por: Hong, A Ram, et al.
Publicado: (2021)

Function of brain-derived neurotrophic factor in the hypothalamus: Implications for depression pathology
por: Autry, Anita E.
Publicado: (2022)

Nobiletin alleviates endometriosis via down-regulating NF-κB activity in endometriosis mouse model
por: Wei, Xin, et al.
Publicado: (2018)

Microglia promote autoimmune inflammation via the noncanonical NF-κB pathway
por: Jie, Zuliang, et al.
Publicado: (2021)

Overview of Research Development on the Role of NF-κB Signaling in Mastitis
por: Khan, Muhammad Zahoor, et al.
Publicado: (2020)

Handbook of the Hypothalamus: Volume 3 (Part A); Behavioral Studies of the Hypothalamus
por: Isseroff, Ami
Publicado: (1981)

Xueliankoufuye Suppresses Microglial Activation with Inflammatory Pain by Blocking NF-κB Signaling Pathway
por: Shao, Shuai, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_b0ln9f39v6b5l4cq4h72dbfre6