Iterative Mechanism of Macrodiolide Formation in the Anticancer Compound Conglobatin

Conglobatin is an unusual C(2)-symmetrical macrodiolide from the bacterium Streptomyces conglobatus with promising antitumor activity. Insights into the genes and enzymes that govern both the assembly-line production of the conglobatin polyketide and its dimerization are essential to allow rational...

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Detalles Bibliográficos
Autores principales: Zhou, Yongjun, Murphy, Annabel C., Samborskyy, Markiyan, Prediger, Patricia, Dias, Luiz Carlos, Leadlay, Peter F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504003/
https://www.ncbi.nlm.nih.gov/pubmed/26091168
http://dx.doi.org/10.1016/j.chembiol.2015.05.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504003/
https://www.ncbi.nlm.nih.gov/pubmed/26091168
http://dx.doi.org/10.1016/j.chembiol.2015.05.010

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