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Iterative Mechanism of Macrodiolide Formation in the Anticancer Compound Conglobatin
Conglobatin is an unusual C(2)-symmetrical macrodiolide from the bacterium Streptomyces conglobatus with promising antitumor activity. Insights into the genes and enzymes that govern both the assembly-line production of the conglobatin polyketide and its dimerization are essential to allow rational...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504003/ https://www.ncbi.nlm.nih.gov/pubmed/26091168 http://dx.doi.org/10.1016/j.chembiol.2015.05.010 |