The Impact of Microenvironmental Heterogeneity on the Evolution of Drug Resistance in Cancer Cells

Therapeutic resistance arises as a result of evolutionary processes driven by dynamic feedback between a heterogeneous cell population and environmental selective pressures. Previous studies have suggested that mutations conferring resistance to epidermal growth factor receptor (EGFR) tyrosine kinas...

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Detalles Bibliográficos
Autores principales: Mumenthaler, Shannon M, Foo, Jasmine, Choi, Nathan C, Heise, Nicholas, Leder, Kevin, Agus, David B, Pao, William, Michor, Franziska, Mallick, Parag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504404/
https://www.ncbi.nlm.nih.gov/pubmed/26244007
http://dx.doi.org/10.4137/CIN.S19338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504404/
https://www.ncbi.nlm.nih.gov/pubmed/26244007
http://dx.doi.org/10.4137/CIN.S19338

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