Cargando…

The Impact of Microenvironmental Heterogeneity on the Evolution of Drug Resistance in Cancer Cells

Therapeutic resistance arises as a result of evolutionary processes driven by dynamic feedback between a heterogeneous cell population and environmental selective pressures. Previous studies have suggested that mutations conferring resistance to epidermal growth factor receptor (EGFR) tyrosine kinas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mumenthaler, Shannon M, Foo, Jasmine, Choi, Nathan C, Heise, Nicholas, Leder, Kevin, Agus, David B, Pao, William, Michor, Franziska, Mallick, Parag
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Libertas Academica 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504404/ https://www.ncbi.nlm.nih.gov/pubmed/26244007 http://dx.doi.org/10.4137/CIN.S19338

Ejemplares similares

Evolutionary Modeling of Combination Treatment Strategies To Overcome Resistance to Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer
por: Mumenthaler, Shannon M., et al.
Publicado: (2011)

Cancer as a moving target: understanding the composition and rebound growth kinetics of recurrent tumors
por: Foo, Jasmine, et al.
Publicado: (2013)

A high-content image-based method for quantitatively studying context-dependent cell population dynamics
por: Garvey, Colleen M., et al.
Publicado: (2016)

Evolution of Resistance to Targeted Anti-Cancer Therapies during Continuous and Pulsed Administration Strategies
por: Foo, Jasmine, et al.
Publicado: (2009)

Correction: Evolution of Resistance to Targeted Anti-Cancer Therapies during Continuous and Pulsed Administration Strategies
por: Foo, Jasmine, et al.
Publicado: (2009)

Fitness Conferred by BCR-ABL Kinase Domain Mutations Determines the Risk of Pre-Existing Resistance in Chronic Myeloid Leukemia
por: Leder, Kevin, et al.
Publicado: (2011)

Microenvironmental Heterogeneity in Brain Malignancies
por: Perus, Lucas J. M., et al.
Publicado: (2019)

An Evolutionary Approach for Identifying Driver Mutations in Colorectal Cancer
por: Foo, Jasmine, et al.
Publicado: (2015)

Leveraging Hypoxia-Activated Prodrugs to Prevent Drug Resistance in Solid Tumors
por: Lindsay, Danika, et al.
Publicado: (2016)

The impact of tumor epithelial and microenvironmental heterogeneity on treatment responses in HER2(+) breast cancer
por: Janiszewska, Michalina, et al.
Publicado: (2021)

Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal cancer evolution and metastatic development
por: Sobral, Daniel, et al.
Publicado: (2022)

Single cell dynamic phenotyping
por: Patsch, Katherin, et al.
Publicado: (2016)

Contribution of the Microenvironmental Niche to Glioblastoma Heterogeneity
por: Ho, Ivy A. W., et al.
Publicado: (2017)

Human colorectal cancer-on-chip model to study the microenvironmental influence on early metastatic spread
por: Strelez, Carly, et al.
Publicado: (2021)

The Therapeutic Implications of Plasticity of the Cancer Stem Cell Phenotype
por: Leder, Kevin, et al.
Publicado: (2010)

Evolutionary Dynamics of Intratumor Heterogeneity
por: Iwasa, Yoh, et al.
Publicado: (2011)

Genomic and microenvironmental heterogeneity shaping epithelial-to-mesenchymal trajectories in cancer
por: Malagoli Tagliazucchi, Guidantonio, et al.
Publicado: (2023)

Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma
por: Jung, Erik, et al.
Publicado: (2021)

Eradication of Chronic Myeloid Leukemia Stem Cells: A Novel Mathematical Model Predicts No Therapeutic Benefit of Adding G-CSF to Imatinib
por: Foo, Jasmine, et al.
Publicado: (2009)

In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies
por: Mercier, Francois E., et al.
Publicado: (2022)

Microenvironmental Signals and Biochemical Information Processing: Cooperative Determinants of Intratumoral Plasticity and Heterogeneity
por: Davies, Alexander E., et al.
Publicado: (2018)

Organ-Specific Endothelial Cell Differentiation and Impact of Microenvironmental Cues on Endothelial Heterogeneity
por: Gifre-Renom, Laia, et al.
Publicado: (2022)

Dose-Dependent Mutation Rates Determine Optimum Erlotinib Dosing Strategies for EGFR Mutant Non-Small Cell Lung Cancer Patients
por: Liu, Lin L., et al.
Publicado: (2015)

DNA secondary structures and epigenetic determinants of cancer genome evolution
por: De, Subhajyoti, et al.
Publicado: (2010)

Microenvironmental Targets in Sarcoma
por: Ehnman, Monika, et al.
Publicado: (2015)

Microenvironmental Heterogeneity Parallels Breast Cancer Progression: A Histology–Genomic Integration Analysis
por: Natrajan, Rachael, et al.
Publicado: (2016)

Patterns of Proliferative Activity in the Colonic Crypt Determine Crypt Stability and Rates of Somatic Evolution
por: Zhao, Rui, et al.
Publicado: (2013)

Tumor and microenvironmental mechanisms of resistance to immunomodulatory drugs in multiple myeloma
por: Chen, Lucia Y., et al.
Publicado: (2022)

Statistical inference of the rates of cell proliferation and phenotypic switching in cancer
por: Gunnarsson, Einar Bjarki, et al.
Publicado: (2023)

Microenvironmental Effects on Enzyme Activity
por: Silman, Israel
Publicado: (1969)

Microenvironmental Regulation by Fibrillin-1
por: Sengle, Gerhard, et al.
Publicado: (2012)

Comparison of Cell and Organoid-Level Analysis of Patient-Derived 3D Organoids to Evaluate Tumor Cell Growth Dynamics and Drug Response
por: Kim, Seungil, et al.
Publicado: (2020)

Editorial: The mechanism of tumor evolution and microenvironmental changes of genitourinary oncology in clinical diagnosis and treatment
por: Lu, Jiahe, et al.
Publicado: (2023)

Cell-of-Origin and Genetic, Epigenetic, and Microenvironmental Factors Contribute to the Intra-Tumoral Heterogeneity of Pediatric Intracranial Ependymoma
por: Servidei, Tiziana, et al.
Publicado: (2021)

Quantifying Tumor Heterogeneity via MRI Habitats to Characterize Microenvironmental Alterations in HER2+ Breast Cancer
por: Kazerouni, Anum S., et al.
Publicado: (2022)

Predictive Modeling of Drug Response in Non-Hodgkin’s Lymphoma
por: Frieboes, Hermann B., et al.
Publicado: (2015)

Microenvironmental modulation of the developing tumour: an immune‐stromal dialogue
por: Jones, James O., et al.
Publicado: (2020)

Microenvironmental arginine depletion by macrophages in vivo.
por: Currie, G. A., et al.
Publicado: (1979)

MICROENVIRONMENTAL INFLUENCES ON ARTICULAR CHONDROCYTE DIFFERENTIATION
por: Chau, Michael, et al.
Publicado: (2020)

Microenvironmental regulation of T-cells in pulmonary hypertension
por: Plecitá-Hlavatá, Lydie, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_24639jj9s2jhk4q7auel0lqsgb