Cilostazol Induces PGI(2) Production via Activation of the Downstream Epac-1/Rap1 Signaling Cascade to Increase Intracellular Calcium by PLCε and to Activate p44/42 MAPK in Human Aortic Endothelial Cells

BACKGROUND: Cilostazol, a selective phosphodiesterase 3 (PDE3) inhibitor, is known as an anti-platelet drug and acts directly on platelets. Cilostazol has been shown to exhibit vascular protection in ischemic diseases. Although vascular endothelium-derived prostaglandin I(2) (PGI(2)) plays an import...

Descripción completa

Detalles Bibliográficos
Autores principales: Hashimoto, Ayako, Tanaka, Michinori, Takeda, Satoshi, Ito, Hideki, Nagano, Keisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504471/
https://www.ncbi.nlm.nih.gov/pubmed/26181635
http://dx.doi.org/10.1371/journal.pone.0132835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504471/
https://www.ncbi.nlm.nih.gov/pubmed/26181635
http://dx.doi.org/10.1371/journal.pone.0132835

Ejemplares similares