Markov State Models Reveal a Two-Step Mechanism of miRNA Loading into the Human Argonaute Protein: Selective Binding followed by Structural Re-arrangement

Argonaute (Ago) proteins and microRNAs (miRNAs) are central components in RNA interference, which is a key cellular mechanism for sequence-specific gene silencing. Despite intensive studies, molecular mechanisms of how Ago recognizes miRNA remain largely elusive. In this study, we propose a two-step...

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Detalles Bibliográficos
Autores principales: Jiang, Hanlun, Sheong, Fu Kit, Zhu, Lizhe, Gao, Xin, Bernauer, Julie, Huang, Xuhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504477/
https://www.ncbi.nlm.nih.gov/pubmed/26181723
http://dx.doi.org/10.1371/journal.pcbi.1004404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504477/
https://www.ncbi.nlm.nih.gov/pubmed/26181723
http://dx.doi.org/10.1371/journal.pcbi.1004404

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