Primary Multiple Pulmonary Primitive Neuroectodermal Tumor: Case Report and Literature Review
Primitive neuroectodermal tumors (PNETs) arising directly from the lung are extremely rare but particularly aggressive neoplasms. Although thoracic PNET usually develops on the chest wall, there have been reports of primary Ewing sarcoma/PNET of the lung. We present the case of a 16-year-old male wi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Wolters Kluwer Health
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504587/ https://www.ncbi.nlm.nih.gov/pubmed/26166119 http://dx.doi.org/10.1097/MD.0000000000001136 |
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author | Dong, Ming Liu, Jinghao Song, Zuoqing Li, Xin Shi, Tao Wang, Dan Ren, Dian Chen, Jun |
author_facet | Dong, Ming Liu, Jinghao Song, Zuoqing Li, Xin Shi, Tao Wang, Dan Ren, Dian Chen, Jun |
author_sort | Dong, Ming |
collection | PubMed |
description | Primitive neuroectodermal tumors (PNETs) arising directly from the lung are extremely rare but particularly aggressive neoplasms. Although thoracic PNET usually develops on the chest wall, there have been reports of primary Ewing sarcoma/PNET of the lung. We present the case of a 16-year-old male with PNET diagnosed following histologic and immunohistochemical examination of a video-assisted thoracic surgical biopsy. As typically occurring for these tumors, the diagnosis was initially delayed in our patient and prognosis was poor despite aggressive surgical resection and postoperative chemotherapy. We attempted to explore the use of targeted pharmacotherapy through high-throughput sequencing in this case. We found that this treatment using Avastin and Cetuximab could provide a new therapeutic direction for PNET. PNENTs arising from the lung parenchyma without pleural or chest wall involvement are extremely rare. Although uncommon, if the pathological features are similar to Ewing sarcoma, PNENTs should be kept in mind, and the target therapy may be a potent treatment for this disease. |
format | Online Article Text |
id | pubmed-4504587 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-45045872015-08-05 Primary Multiple Pulmonary Primitive Neuroectodermal Tumor: Case Report and Literature Review Dong, Ming Liu, Jinghao Song, Zuoqing Li, Xin Shi, Tao Wang, Dan Ren, Dian Chen, Jun Medicine (Baltimore) 6700 Primitive neuroectodermal tumors (PNETs) arising directly from the lung are extremely rare but particularly aggressive neoplasms. Although thoracic PNET usually develops on the chest wall, there have been reports of primary Ewing sarcoma/PNET of the lung. We present the case of a 16-year-old male with PNET diagnosed following histologic and immunohistochemical examination of a video-assisted thoracic surgical biopsy. As typically occurring for these tumors, the diagnosis was initially delayed in our patient and prognosis was poor despite aggressive surgical resection and postoperative chemotherapy. We attempted to explore the use of targeted pharmacotherapy through high-throughput sequencing in this case. We found that this treatment using Avastin and Cetuximab could provide a new therapeutic direction for PNET. PNENTs arising from the lung parenchyma without pleural or chest wall involvement are extremely rare. Although uncommon, if the pathological features are similar to Ewing sarcoma, PNENTs should be kept in mind, and the target therapy may be a potent treatment for this disease. Wolters Kluwer Health 2015-07-13 /pmc/articles/PMC4504587/ /pubmed/26166119 http://dx.doi.org/10.1097/MD.0000000000001136 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 6700 Dong, Ming Liu, Jinghao Song, Zuoqing Li, Xin Shi, Tao Wang, Dan Ren, Dian Chen, Jun Primary Multiple Pulmonary Primitive Neuroectodermal Tumor: Case Report and Literature Review |
title | Primary Multiple Pulmonary Primitive Neuroectodermal Tumor: Case Report and Literature Review |
title_full | Primary Multiple Pulmonary Primitive Neuroectodermal Tumor: Case Report and Literature Review |
title_fullStr | Primary Multiple Pulmonary Primitive Neuroectodermal Tumor: Case Report and Literature Review |
title_full_unstemmed | Primary Multiple Pulmonary Primitive Neuroectodermal Tumor: Case Report and Literature Review |
title_short | Primary Multiple Pulmonary Primitive Neuroectodermal Tumor: Case Report and Literature Review |
title_sort | primary multiple pulmonary primitive neuroectodermal tumor: case report and literature review |
topic | 6700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504587/ https://www.ncbi.nlm.nih.gov/pubmed/26166119 http://dx.doi.org/10.1097/MD.0000000000001136 |
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