Human Nav1.6 Channels Generate Larger Resurgent Currents than Human Nav1.1 Channels, but the Navβ4 Peptide Does Not Protect Either Isoform from Use-Dependent Reduction

Voltage-gated sodium channels are responsible for the initiation and propagation of action potentials (APs). Two brain isoforms, Nav1.1 and Nav1.6, have very distinct cellular and subcellular expression. Specifically, Nav1.1 is predominantly expressed in the soma and proximal axon initial segment of...

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Detalles Bibliográficos
Autores principales: Patel, Reesha R., Barbosa, Cindy, Xiao, Yucheng, Cummins, Theodore R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504674/
https://www.ncbi.nlm.nih.gov/pubmed/26182346
http://dx.doi.org/10.1371/journal.pone.0133485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504674/
https://www.ncbi.nlm.nih.gov/pubmed/26182346
http://dx.doi.org/10.1371/journal.pone.0133485

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