Allostery through the computational microscope: cAMP activation of a canonical signaling domain

Ligand-induced protein allostery plays a central role in modulating cellular signaling pathways. Here, using the conserved cyclic-nucleotide binding domain of protein kinase A’s (PKA) regulatory subunit as a prototype signaling unit, we combine long-timescale, all-atom molecular dynamics simulations...

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Detalles Bibliográficos
Autores principales: Malmstrom, Robert D., Kornev, Alexandr P., Taylor, Susan S., Amaro, Rommie E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504738/
https://www.ncbi.nlm.nih.gov/pubmed/26145448
http://dx.doi.org/10.1038/ncomms8588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504738/
https://www.ncbi.nlm.nih.gov/pubmed/26145448
http://dx.doi.org/10.1038/ncomms8588

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