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Allostery through the computational microscope: cAMP activation of a canonical signaling domain
Ligand-induced protein allostery plays a central role in modulating cellular signaling pathways. Here, using the conserved cyclic-nucleotide binding domain of protein kinase A’s (PKA) regulatory subunit as a prototype signaling unit, we combine long-timescale, all-atom molecular dynamics simulations...
Autores principales: | Malmstrom, Robert D., Kornev, Alexandr P., Taylor, Susan S., Amaro, Rommie E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504738/ https://www.ncbi.nlm.nih.gov/pubmed/26145448 http://dx.doi.org/10.1038/ncomms8588 |
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