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Premature aging of the hippocampal neurogenic niche in adult Bmal1‐ deficient mice
Hippocampal neurogenesis undergoes dramatic age‐related changes. Mice with targeted deletion of the clock gene Bmal1 (Bmal1(‐/‐)) show disrupted regulation of reactive oxygen species homeostasis, accelerated aging, neurodegeneration and cognitive deficits. As proliferation of neuronal progenitor/pre...
Autores principales: | Ali, Amira A. H., Schwarz‐Herzke, Beryl, Stahr, Anna, Prozorovski, Timour, Aktas, Orhan, von Gall, Charlotte |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505169/ https://www.ncbi.nlm.nih.gov/pubmed/26142744 |
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