Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging

The antifungal drug posaconazole has shown significant activity against Trypanosoma cruzi in vitro and in experimental murine models. Despite this, in a recent clinical trial it displayed limited curative potential. Drug testing is problematic in experimental Chagas disease because of difficulties i...

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Detalles Bibliográficos
Autores principales: Francisco, Amanda Fortes, Lewis, Michael D., Jayawardhana, Shiromani, Taylor, Martin C., Chatelain, Eric, Kelly, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2015
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505219/
https://www.ncbi.nlm.nih.gov/pubmed/26014936
http://dx.doi.org/10.1128/AAC.00520-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505219/
https://www.ncbi.nlm.nih.gov/pubmed/26014936
http://dx.doi.org/10.1128/AAC.00520-15

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