Combinations of β-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection

We report here a dehydropeptidase-deficient murine model of tuberculosis (TB) infection that is able to partially uncover the efficacy of marketed broad-spectrum β-lactam antibiotics alone and in combination. Reductions of up to 2 log CFU in the lungs of TB-infected mice after 8 days of treatment co...

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Detalles Bibliográficos
Autores principales: Rullas, Joaquín, Dhar, Neeraj, McKinney, John D., García-Pérez, Adolfo, Lelievre, Joël, Diacon, Andreas H., Hugonnet, Jean-Emmanuel, Arthur, Michel, Angulo-Barturen, Iñigo, Barros-Aguirre, David, Ballell, Lluís
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2015
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505286/
https://www.ncbi.nlm.nih.gov/pubmed/25987618
http://dx.doi.org/10.1128/AAC.01063-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505286/
https://www.ncbi.nlm.nih.gov/pubmed/25987618
http://dx.doi.org/10.1128/AAC.01063-15

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