Selective targeting of PPARγ by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency

Type 2 diabetes mellitus (T2DM) is a pervasive metabolic syndrome that is characterized by insulin resistance, hyperglycemia and dyslipidemia. As full agonists of PPARγ, thiazolidinedione (TZD) drugs elicit antidiabetic effects by targeting PPARγ but is accompanied by weight gain, fluid retention an...

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Detalles Bibliográficos
Autores principales: Zheng, Weili, Qiu, Lin, Wang, Rui, Feng, Xuhui, Han, Yaping, Zhu, Yanlin, Chen, Dezhou, Liu, Yijie, Jin, Lihua, Li, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505335/
https://www.ncbi.nlm.nih.gov/pubmed/26183621
http://dx.doi.org/10.1038/srep12222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505335/
https://www.ncbi.nlm.nih.gov/pubmed/26183621
http://dx.doi.org/10.1038/srep12222

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