Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay

The prion protein (PrP) has been implicated both in prion diseases such as Creutzfeldt-Jakob disease, where its monomeric cellular isoform (PrP(C)) is recruited into pathogenic self-propagating polymers of misfolded protein, and in Alzheimer disease, where PrP(C) may act as a receptor for synaptotox...

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Detalles Bibliográficos
Autores principales: Risse, Emmanuel, Nicoll, Andrew J., Taylor, William A., Wright, Daniel, Badoni, Mayank, Yang, Xiaofan, Farrow, Mark A., Collinge, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505445/
https://www.ncbi.nlm.nih.gov/pubmed/25995455
http://dx.doi.org/10.1074/jbc.M115.637124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505445/
https://www.ncbi.nlm.nih.gov/pubmed/25995455
http://dx.doi.org/10.1074/jbc.M115.637124

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