Cytokinetic Failure-induced Tetraploidy Develops into Aneuploidy, Triggering Skin Aging in Phosphovimentin-deficient Mice

Tetraploidy, a state in which cells have doubled chromosomal sets, is observed in ∼20% of solid tumors and is considered to frequently precede aneuploidy in carcinogenesis. Tetraploidy is also detected during terminal differentiation and represents a hallmark of aging. Most tetraploid cultured cells...

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Detalles Bibliográficos
Autores principales: Tanaka, Hiroki, Goto, Hidemasa, Inoko, Akihito, Makihara, Hiroyuki, Enomoto, Atsushi, Horimoto, Katsuhisa, Matsuyama, Makoto, Kurita, Kenichi, Izawa, Ichiro, Inagaki, Masaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505553/
https://www.ncbi.nlm.nih.gov/pubmed/25847236
http://dx.doi.org/10.1074/jbc.M114.633891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505553/
https://www.ncbi.nlm.nih.gov/pubmed/25847236
http://dx.doi.org/10.1074/jbc.M114.633891

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