A Salt Bridge Linking the First Intracellular Loop with the C Terminus Facilitates the Folding of the Serotonin Transporter

The folding trajectory of solute carrier 6 (SLC6) family members is of interest because point mutations result in misfolding and thus cause clinically relevant phenotypes in people. Here we examined the contribution of the C terminus in supporting folding of the serotonin transporter (SERT; SLC6A4)....

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Detalles Bibliográficos
Autores principales: Koban, Florian, El-Kasaby, Ali, Häusler, Cornelia, Stockner, Thomas, Simbrunner, Benedikt M., Sitte, Harald H., Freissmuth, Michael, Sucic, Sonja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505579/
https://www.ncbi.nlm.nih.gov/pubmed/25869136
http://dx.doi.org/10.1074/jbc.M115.641357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505579/
https://www.ncbi.nlm.nih.gov/pubmed/25869136
http://dx.doi.org/10.1074/jbc.M115.641357

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