A Mechanistic Pharmacokinetic Model for Liver Transporter Substrates Under Liver Cirrhosis Conditions

Liver cirrhosis is a disease characterized by the loss of functional liver mass. Physiologically based pharmacokinetic (PBPK) modeling was applied to interpret and predict how the interplay among physiological changes in cirrhosis affects pharmacokinetics. However, previous PBPK models under cirrhot...

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Detalles Bibliográficos
Autores principales: Li, R, Barton, HA, Maurer, TS
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505828/
https://www.ncbi.nlm.nih.gov/pubmed/26225262
http://dx.doi.org/10.1002/psp4.39

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505828/
https://www.ncbi.nlm.nih.gov/pubmed/26225262
http://dx.doi.org/10.1002/psp4.39

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