Semiphysiologically Based Pharmacokinetic Model of Leflunomide Disposition in Rheumatoid Arthritis Patients

A semiphysiologically based pharmacokinetic (semi-PBPK) population model was used to evaluate the influence of enterohepatic recycling and protein binding, as well as the effect of genetic variability in CYP1A2, CYP2C19, and ABCG2, on the large interindividual variability of teriflunomide (active me...

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Detalles Bibliográficos
Autores principales: Hopkins, AM, Wiese, MD, Proudman, SM, O'Doherty, CE, Foster, DJR, Upton, RN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505830/
https://www.ncbi.nlm.nih.gov/pubmed/26225264
http://dx.doi.org/10.1002/psp4.46

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505830/
https://www.ncbi.nlm.nih.gov/pubmed/26225264
http://dx.doi.org/10.1002/psp4.46

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