Glutathione Transferase Gene Variants Influence Busulfan Pharmacokinetics and Outcome After Myeloablative Conditioning

BACKGROUND: Busulfan (Bu) and cyclophosphamide (Cy) are frequently included in conditioning regimens before hematopoietic stem cell transplantation (HSCT). Both drugs are detoxified by glutathione transferases (GST), and GST gene variants may explain some of the interindividual variability in pharma...

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Detalles Bibliográficos
Autores principales: Bremer, Sara, Fløisand, Yngvar, Brinch, Lorentz, Gedde-Dahl, Tobias, Bergan, Stein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Therapeutic Drug Monitoring 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505914/
https://www.ncbi.nlm.nih.gov/pubmed/25565670
http://dx.doi.org/10.1097/FTD.0000000000000180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505914/
https://www.ncbi.nlm.nih.gov/pubmed/25565670
http://dx.doi.org/10.1097/FTD.0000000000000180

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