Cargando…

Vimentin Phosphorylation Underlies Myofibroblast Sensitivity to Withaferin A In Vitro and during Corneal Fibrosis

Vimentin is a newly recognized target for corneal fibrosis. Using primary rabbit corneal fibroblasts and myofibroblasts we show that myofibroblasts, unlike fibroblasts, display impaired cell spreading and cell polarization, which is associated with increased levels of soluble serine-38 phosphorylate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bargagna-Mohan, Paola, Lei, Ling, Thompson, Alexis, Shaw, Camille, Kasahara, Kousuke, Inagaki, Masaki, Mohan, Royce
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506086/ https://www.ncbi.nlm.nih.gov/pubmed/26186445 http://dx.doi.org/10.1371/journal.pone.0133399

Ejemplares similares

Withaferin A Effectively Targets Soluble Vimentin in the Glaucoma Filtration Surgical Model of Fibrosis
por: Bargagna-Mohan, Paola, et al.
Publicado: (2013)

A robust model for simultaneously inducing corneal neovascularization and retinal gliosis in the mouse eye
por: Paranthan, Riya R., et al.
Publicado: (2011)

Vimentin Phosphorylation Is Required for Normal Cell Division of Immature Astrocytes
por: de Pablo, Yolanda, et al.
Publicado: (2019)

Corneal nonmyelinating Schwann cells illuminated by single‐cell transcriptomics and visualized by protein biomarkers
por: Bargagna‐Mohan, Paola, et al.
Publicado: (2020)

Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis
por: Yamaguchi, Tomoya, et al.
Publicado: (2005)

Increased Phosphorylation of Vimentin in Noninfiltrative Meningiomas
por: Bouamrani, Ali, et al.
Publicado: (2010)

Defect of Mitotic Vimentin Phosphorylation Causes Microophthalmia and Cataract via Aneuploidy and Senescence in Lens Epithelial Cells
por: Matsuyama, Makoto, et al.
Publicado: (2013)

In wound repair vimentin mediates the transition of mesenchymal leader cells to a myofibroblast phenotype
por: Walker, J. L., et al.
Publicado: (2018)

Intermediate filaments and IF-associated proteins: from cell architecture to cell proliferation
por: NISHIMURA, Yuhei, et al.
Publicado: (2019)

Inhibition of Human Corneal Myofibroblast Formation
por: Guo, Xiaoqing, et al.
Publicado: (2018)

PI 3-kinase-dependent phosphorylation of Plk1–Ser99 promotes association with 14-3-3γ and is required for metaphase–anaphase transition
por: Kasahara, Kousuke, et al.
Publicado: (2013)

Immunohistochemical Analysis of Vimentin in Oral Submucous Fibrosis
por: Nayak, Meghanand T., et al.
Publicado: (2013)

Current topics of functional links between primary cilia and cell cycle
por: Izawa, Ichiro, et al.
Publicado: (2015)

Implications of Withaferin A in neurological disorders
por: Ram, Natasha, et al.
Publicado: (2020)

Myofibroblasts: Master of disguise
por: Bagalad, Bhavana S, et al.
Publicado: (2017)

Vimentin organization modulates the formation of lamellipodia
por: Helfand, Brian T., et al.
Publicado: (2011)

ROCK is Involved in Vimentin Phosphorylation and Rearrangement Induced by Dengue Virus
por: Lei, Shun, et al.
Publicado: (2013)

Acetylcholine decreases formation of myofibroblasts and excessive extracellular matrix production in an in vitro human corneal fibrosis model
por: Słoniecka, Marta, et al.
Publicado: (2020)

Blocking Mitochondrial Pyruvate Transport Alters Corneal Myofibroblast Phenotype: A New Target for Treating Fibrosis
por: Jeon, Kye-Im, et al.
Publicado: (2023)

Host Cell Vimentin Restrains Toxoplasma gondii Invasion and Phosphorylation of Vimentin is Partially Regulated by Interaction with TgROP18
por: He, Cheng, et al.
Publicado: (2017)

Plasma Membrane Localization of CD36 Requires Vimentin Phosphorylation; A Mechanism by Which Macrophage Vimentin Promotes Atherosclerosis
por: Kim, Seo Yeon, et al.
Publicado: (2022)

Origin of myofibroblasts in liver fibrosis
por: Brenner, David A, et al.
Publicado: (2012)

Extracellular Vesicles Secreted by Corneal Myofibroblasts Promote Corneal Epithelial Cell Migration
por: Yeung, Vincent, et al.
Publicado: (2022)

Compartmentalized citrullination in Muller glial endfeet during retinal degeneration
por: Palko, Sarah I., et al.
Publicado: (2022)

Defining the Role of Mitochondrial Fission in Corneal Myofibroblast Differentiation
por: Jeon, Kye-Im, et al.
Publicado: (2022)

Andrographolide Inhibits Corneal Fibroblast to Myofibroblast Differentiation In Vitro
por: Rozo, Vanessa, et al.
Publicado: (2022)

Vimentin phosphorylation and assembly are regulated by the small GTPase Rab7a
por: Cogli, Laura, et al.
Publicado: (2013)

RAB7A Regulates Vimentin Phosphorylation through AKT and PAK
por: Romano, Roberta, et al.
Publicado: (2021)

Withaferin-A Reduces Type I Collagen Expression In Vitro and Inhibits Development of Myocardial Fibrosis In Vivo
por: Challa, Azariyas A., et al.
Publicado: (2012)

Inhibition of NFκB by the natural product Withaferin A in cellular models of Cystic Fibrosis inflammation
por: Maitra, Rangan, et al.
Publicado: (2009)

Primary Cilia as Signaling Hubs in Health and Disease
por: Nishimura, Yuhei, et al.
Publicado: (2018)

Phosphorylation of keratin and vimentin polypeptides in normal and transformed mitotic human epithelial amnion cells: behavior of keratin and vimentin filaments during mitosis
Publicado: (1983)

Lung Fibrosis and Fibrosis in the Lungs: Is It All about Myofibroblasts?
por: Ortiz-Zapater, Elena, et al.
Publicado: (2022)

Design and Synthesis of New Withaferin A Inspired Hedgehog Pathway Inhibitors
por: Bonandi, Elisa, et al.
Publicado: (2021)

Topical Losartan and Corticosteroid Additively Inhibit Corneal Stromal Myofibroblast Generation and Scarring Fibrosis After Alkali Burn Injury
por: Sampaio, Lycia Pedral, et al.
Publicado: (2022)

Novel Combination BMP7 and HGF Gene Therapy Instigates Selective Myofibroblast Apoptosis and Reduces Corneal Haze In Vivo
por: Gupta, Suneel, et al.
Publicado: (2018)

Withaferin A is a Leptin Sensitizer with Strong Anti-Diabetic Properties in Mice
por: Lee, Jaemin, et al.
Publicado: (2016)

Corneal myofibroblasts inhibit regenerating nerves during wound healing
por: Jeon, Kye-Im, et al.
Publicado: (2018)

An Adaptogen: Withaferin A Ameliorates in Vitro and in Vivo Pulmonary Fibrosis by Modulating the Interplay of Fibrotic, Matricelluar Proteins, and Cytokines
por: Bale, Swarna, et al.
Publicado: (2018)

Cell configuration-related control of vimentin biosynthesis and phosphorylation in cultured mammalian cells
Publicado: (1983)

Cannot write session to /tmp/vufind_sessions/sess_f6rcl6c2mcnodorra86eo9msl3