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Vimentin Phosphorylation Underlies Myofibroblast Sensitivity to Withaferin A In Vitro and during Corneal Fibrosis
Vimentin is a newly recognized target for corneal fibrosis. Using primary rabbit corneal fibroblasts and myofibroblasts we show that myofibroblasts, unlike fibroblasts, display impaired cell spreading and cell polarization, which is associated with increased levels of soluble serine-38 phosphorylate...
Autores principales: | Bargagna-Mohan, Paola, Lei, Ling, Thompson, Alexis, Shaw, Camille, Kasahara, Kousuke, Inagaki, Masaki, Mohan, Royce |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506086/ https://www.ncbi.nlm.nih.gov/pubmed/26186445 http://dx.doi.org/10.1371/journal.pone.0133399 |
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