Leaky RAG Deficiency in Adult Patients with Impaired Antibody Production against Bacterial Polysaccharide Antigens

Loss of function mutations in the recombination activating genes RAG1 and RAG2 have been reported to cause a T(-)B(-)NK(+) type of severe combined immunodeficiency. In addition identification of hypomorphic mutations in RAG1 and RAG2 has led to an expansion of the spectrum of disease to include Omen...

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Detalles Bibliográficos
Autores principales: Geier, Christoph B., Piller, Alexander, Linder, Angela, Sauerwein, Kai M. T., Eibl, Martha M., Wolf, Hermann M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506145/
https://www.ncbi.nlm.nih.gov/pubmed/26186701
http://dx.doi.org/10.1371/journal.pone.0133220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506145/
https://www.ncbi.nlm.nih.gov/pubmed/26186701
http://dx.doi.org/10.1371/journal.pone.0133220

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